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Š. m. birželio 10 d., antradienį, 11 val. VU Gamtos mokslų fakulteto Biofizikos auditorijoje (242 kabinete) Prof. Peter D. Nagy (Augalų patologijos katedra, Kentukio universitetas, JAV) skaitys pranešimą „How yeast could be used as a genetic platform to explore virus-host interactions: from „omics“ to functional studies“.
Yeast (Saccharomyces cerevisiae) is an advanced model organism that has emerged as an effective host to gain insights into the intricate interactions of viruses with host cells. RNA viruses have limited coding potential and they have to co-opt numerous host cellular factors to facilitate their replication. To identify those host factors subverted by viruses, high-throughput genomics and global proteomics approaches have been performed with plant viruses, such as tomato bushy stunt virus (TBSV). Accordingly, several hundred of susceptibility and restriction factors for TBSV have been identified using yeast as a model host. Amazingly, host factors affecting viral genetic recombination and evolution have also been identified in genome-wide screens in yeast. The roles of many yeast host factors involved in various steps of the viral replication process have been validated by exploiting the orthologous genes in plant hosts. This seminar gives new insights into our understanding of virus-host interactions.